Richard “Dick” McCarthy is a very active senior. At 83, the Vermont native still loves to play pickleball, ride his bicycle, swim and golf. The retired history teacher and soccer coach has paid a price for his activity and longevity. For years, he battled the agony of arthritis in his knees.
“I had an aching pain in both of my knees,” he confirms. Dick was diagnosed by his physician with osteoarthritis, which is the wear-and-tear type that generally occurs with age. Along with the destruction of the cushioning cartilage in the joints typical of osteoarthritis, the lubricating fluid, called synovial fluid, also begins to thin over time. “Over the past four years, my orthopedic surgeon has given me synthetic synovial fluid shots into my knees,” shares Dick. “The first time he gave me the injections, the pain relief lasted about two years. The second time, it lasted probably six months. Then, in October of last year, I had the injections done again, and that lasted three months. They just weren’t doing the job."
“RegenMax is a proprietary formulation of the highest-quality stem cells, platelets and other bioactive growth factors,” describes Jason. “The cells and growth factors work together to stimulate healing in an arthritic or injured joint. “Dick was an active senior, and was having significant pain due to bone-on-bone degenerative arthritis. He was looking for nonsurgical treatment options that would substantially reduce his pain so he could continue doing his activities. We treated him with RegenMax Injection Therapy, and he like most patients had a very positive response.”
In the phase I safety trial, a single injection of adipose tissue derived stem cells into the knee patients was safe and well tolerated.
The stem cell treatment also showed durable and clinically meaningful pain relief in patients with knee osteoarthritis.
Examination of knee joint structure by MRI showed a statistically significant improvement in lateral tibial cartilage volume for patients treated with the stem cells. This result compared to a worsening in volume in placebo patients.
The research showed the stem cells work by secreting cytokines, growth factors and exosomes that act in concert to reduce inflammation and pain, and encourage accelerated healing and repair of damaged or diseased tissue.
ANAHEIM, Calif. -- Garrett Richards is expected to be ready for spring training after the Los Angeles Angels right-hander completed his instructional league work with no problems in his right elbow.
Richards had a platelet-rich plasma injection on Friday, the Angels announced. Richards also was examined by Dr. Steve Yoon, who saw continued healing in the pitcher's partially torn elbow ligament.
Richards is hoping to avoid Tommy John surgery with rest, stem-cell therapy and PRP injections. He completed three instructional league outings this month with no setbacks.
Many of the traditional procedures people undergo to counter chronic knee pain in the hopes of avoiding a knee replacement have limited or no evidence to support them. Serious questions are now being raised about the benefits of the arthroscopic procedures that millions of people endure in hopes of delaying, if not avoiding, total knee replacements.
The latest challenge, published in May in BMJ by an expert panel that systematically reviewed 12 well-designed trials and 13 observational studies, concluded that arthroscopic surgery for degenerative knee arthritis and meniscal tears resulted in no lasting pain relief or improved function.
Three months after the procedure, fewer than 15 percent of patients experienced at best “a small or very small improvement in pain and function,” effects that disappeared completely within a year.
Other common interventions include steroid injections into the knee. These can reduce painful inflammation, but if used repeatedly, steroids can speed the development of arthritis in the joint. A study published in May in JAMA by researchers at Tufts Medical Center found that the injection of a corticosteroid every three months over two years resulted in greater loss of knee cartilage and no significant difference in knee pain compared to patients who received a placebo injection.
JACKSONVILLE, FL — Researchers at the Mayo Clinic have conducted the world’s first prospective, blinded and placebo-controlled clinical study to test the benefit of stem cells to reduce arthritic pain and disability in knees.
Patients not only had a dramatic improvement in the knee that received stem cells, but also in their other knee, which also had painful arthritis but received only a saline control injection. Each of the 25 patients enrolled in the study had two bad knees, but did not know which knee received the stem cells.
“Our findings can be interpreted in ways that we now need to test — one of which is that stem cell injection in one ailing knee can relieve pain in both affected knees in a systemic or whole-body fashion,” says the study’s lead author, Shane Shapiro, M.D., a Mayo Clinic orthopedic physician.
A total of 1128 patients underwent standard liposuction under local anesthesia and SVF cells were isolated and prepared for application into 1-4 large joints. A total of 1856 joints, mainly knee and hip joints, were treated with a single dose of SVF cells. 1114 patients were followed for 12.1-54.3 months (median 17.2 months) for safety and efficacy.
No serious side effects, systemic infection or cancer was associated with SVF cell therapy. Most patients gradually improved 3-12 months after the treatment. At least 75% Score improvement was noticed in 63% of patients and at least 50% Score improvement was documented in 91% of patients 12 months after SVF cell therapy. Obesity and higher grade of OA were associated with slower healing. In conclusion, here we report a novel and promising treatment approach for patients with degenerative OA that is safe, cost-effective, and relying only on autologous cells.
Miami Dolphins center Mike Pouncey underwent a stem cell procedure as part of his recovery from a season-ending hip injury, the Palm Beach Post's Joe Schad reported Monday.
According to ESPN.com's James Walker, Pouncey's rehab is progressing as expected and that Dolphins head coach Adam Gase expects to have Pouncey healthy for the first week of the regular season.
OAKLAND, Calif. -- Starting point guard D'Angelo Russell will miss at least two weeks after receiving a platelet-rich plasma injection in his sore left knee, the Los Angeles Lakers announced Wednesday.
Dr. Steve Yoon performed the procedure in Los Angeles. The Lakers said Russell will be re-evaluated in one week.
Lakers coach Luke Walton said he didn't think Russell would need surgery.
In the this study, adipose-derived stem cell therapy for elderly patients with knee osteoarthritis (OA) was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment can be a good option for OA treatment in elderly patients.
Avascular necrosis (AVN) of the femoral head is a devastating joint disease. The disease is characterized by decreased blood flow to the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes with severe pain, and the disease course rarely regresses. Current treatment options have been disappointing, with up to 40 percent of patients progressing to total hip arthroplasty.
Mayo Clinic researchers recently began studying the use of concentrated stem cell therapy and platelet-rich plasma (PRP) as adjuvants to minimally invasive decompression to treat patients with AVN.
Significant pain relief was reported in 86 percent of patients!
Boston Celtics All-Star point guard Isaiah Thomas received a Platelet-Rich Plasma, or PRP, injection for a groin strain. Thomas said, "I'm going to do whatever I can to get back out there on the court. It's eating me alive to not be able to participate, not to be able to play, but I gotta be smart about this because I don't want this to linger on for the rest of the season. I gotta do what is best for my body."
"We studied patients 35 to 60 years old with rotator cuff tendinopathy due to normal aging. For the first time, we were able to not only find reported improvements in pain and mobility, but also in the tissue - the MRI before and after showed structural change and a decrease in the size of tears," says Marni Wesner, sports medicine physician at the Glen Sather Sports Medicine Clinic.
Cutting-edge techniques that harness the body’s natural regenerative power can help soldiers recover from traumatic injuries. This technique, termed interventional orthopedics, is minimally invasive and can replace surgery or speed the healing process after surgery—sometimes cutting recovery time from months to just weeks.
The Regenerative Biologics Institute, or RBI, has opened a state-of-the-art facility in Vero Beach, FL to offer innovative stem cell therapy and PRP therapy to patients on the Treasure Coast and throughout Florida. RBI is the first of its kind center of excellence in the area that specializes in minimally-invasive regenerative therapies and is complete with a dedicated biologics laboratory. RBI also utilizes advanced image guidance technology including ultrasound and even live x-ray for precise delivery of therapeutics into certain areas of the body like the spine. Regenerative Medicine is an innovative approach that utilizes a patient’s own natural regenerative ability in the form of stem cells and platelets to treat degenerative conditions, sports injuries and more. The field has been recognized worldwide as one that offers the potential to dramatically impact patient care in the 21st century.